Denizens of Lux have come to call it "The City" and treat it as a sentient force. Three factions vie for control of the city: the Organo, a strictly professional conglomerate with ties to the criminal underworld in the prosthetics business; the Union, a fanatical populist group interfering with Organo's affairs; and Racan, a marauding group of Texhnolyzed youths.

For over a century, the mysterious Hellsing Organization has been secretly protecting the British Empire from the undead. When Sir Integra Hellsing succeeded as the head of the organization, she also inherited the ultimate weapon against these supernatural enemies: Alucard, a rogue vampire possessing mysterious and frightening powers. Now, Hellsing must deal with a more dangerous threat than vampires.